Pair Name	Luteolin, Cisplatin
Disease Info	[ICD-11: 2B72.Z]	Gastric cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Up-regulation	Expression	BAX	hsa581
	Down-regulation	Expression	BCL2	hsa596
	Up-regulation	Expression	CASP3	hsa836
	Up-regulation	Expression	CASP6	hsa839
	Up-regulation	Expression	CASP9	hsa842
	Down-regulation	Expression	CCNB1	hsa891
	Down-regulation	Expression	POLD1	hsa5424
	Up-regulation	Expression	TP53	hsa7157
In Vitro Model	AGS	Gastric adenocarcinoma	Homo sapiens (Human)	CVCL_0139
Result	These findings indicate the anti-proliferative and chemosensitizing effects of luteolin on human gastric cancer AGS cells and luteolin may be a promising candidate agent used in the treatment of gastric cancer.

Pair Name	Luteolin, Cisplatin
Disease Info	[ICD-11: 2B91.Z]	Colorectal cancer		Investigative
In Vitro Model	HCT 116	Colon carcinoma	Homo sapiens (Human)	CVCL_0291
	BEAS-2B	Healthy	Homo sapiens (Human)	CVCL_0168
In Vivo Model	To generate HCT116 xenografts in BALB/c nude mice, 3 × 106 HCT116 cells were subcutaneously injected into the left and right flanks of each mouse.
Result	The Determination of Cisplatin and Luteolin Synergistic Effect on Colorectal Cancer Cell Apoptosis and Mitochondrial Dysfunction by Fluorescence Labelling